Development of cancer vaccine therapy by targeting cell cycle of cancer stem cell

2014 Fiscal Year Final Research Report

• Project/Area Number: 24591981
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Wakayama Medical University
• Principal Investigator: MATSUDA Kenji 和歌山県立医科大学, 医学部, 講師 (30398458)
• Co-Investigator(Kenkyū-buntansha): YAMAUE Hiroki 和歌山県立医科大学, 医学部, 教授 (20191190) ; HOTTA Tsukasa 和歌山県立医科大学, 医学部, 教授 (50244744) ; KATSUDA Masahiro 和歌山県立医科大学, 医学部, 助教 (50464673) ; IWAHASHI Makoto 和歌山県立医科大学, 医学部, 博士研究員 (70244738) ; YOKOYAMA Shozo 和歌山県立医科大学, 医学部, 講師 (90398462)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: PML / peptide

Outline of Final Research Achievements

We have targeted PML which reportedly regulate cell cycle. We have expected　that cancer stem cell was thrown out from G0 status by targeting PML and which increases chemosinsitivety. We have assesed the correlation between the expression of PML and chemosensitivity. We have not found out a significant relation up to the present. On the other hand, we have shown the possibility of PML targeted cancer vaccine therapy by using TLR ligand in mouse model.

Free Research Field

大腸肛門病学