Development of implantable artificial myocardial assist device for right ventricular support

2014 Fiscal Year Final Research Report

• Project/Area Number: 24592048
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Thoracic surgery
• Research Institution: Tohoku University
• Principal Investigator: MASUDA SHINYA 東北大学, 医学(系)研究科(研究院), 非常勤講師 (30596094)
• Co-Investigator(Kenkyū-buntansha): SHIBUYA Takumi 東北大学, 大学院医学系研究科, 非常勤講師 (10526453) ; KAWAMOTO Shunsuke 東北大学, 大学院医学系研究科, 准教授 (20400244) ; SAIKI Yoshikatsu 東北大学, 大学院医学系研究科, 教授 (50372298) ; YANBE Tomoyuki 東北大学, 加齢医学研究所, 教授 (70241578) ; AKIYAMA Masatoshi 東北大学, 病院, 講師 (80526450)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 右心不全 / 人工心筋 / 右心不全モデル / 心臓外科 / 人工心臓

Outline of Final Research Achievements

We confirmed a supporting effect in Mock circuit and decided a structure of the device and made a canine right heart failure model by injected ethanol to a free wall of right ventricle. After 2 weeks on injection ethanol, in a canine model, RVSW reduced and a pathological liver congestion was revealed. We carried out an acute experiment for a right heart failure model with a device of artificial myocardium. The device of artificial myocardium led the increase of left ventricular end-diastolic volume. We would improve this device and perform the chronic experiment for effectiveness.

Free Research Field

医歯薬学