2014 Fiscal Year Final Research Report
The effect of anesthetics on inhibitory networks in the central nucleus of amygdala
| Project/Area Number |
24592324
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | University of Tsukuba |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
KATO Fusao 慈恵会医科大学, 医学部, 教授 (20169519)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 扁桃体 / ノルアドレナリン / GABA |
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| Outline of Final Research Achievements |
Pain promotes aversive memory formation and in turn exacerbates psycho-mental complications in the chronic pain patients. The central nucleus of amygdala plays essential role in emotional memory formation. Noradrenaline is a primary stress hormone in the CNS.
We clarified that noradrenaline dramatically and reversibly increased inhibitory input to the medial division of the central nucleus of amygdala (CeM). A possible interpretation is that CeM neuron excitability is regulated by inhibitory inputs from the lateral and capsular divisions of CeA through alpha-1 receptor-mediated processes and from unidentified cell populations that are excited by beta receptor activation.
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| Free Research Field |
麻酔、神経生理学
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