Study on quantification of the living body involvement by the active oxygen measurement

2014 Fiscal Year Final Research Report

• Project/Area Number: 24592347
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Anesthesiology/Resuscitation studies
• Research Institution: Kagoshima University
• Principal Investigator: OWAKI TETSUHIRO 鹿児島大学, 医歯(薬)学総合研究科, 教授 (50322318)
• Co-Investigator(Kenkyū-buntansha): NEROME Yasuhito 鹿児島大学, 大学院医歯学総合研究科, 准教授 (00457657) ; OKUMURA Hiroshi 鹿児島大学, 大学院医歯学総合研究科, 講師 (10398282) ; UENO Shinichi 鹿児島大学, 大学院医歯学総合研究科, 特任教授 (40322317) ; NATSUGOE Shoji 鹿児島大学, 大学院医歯学総合研究科, 教授 (70237577)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 手術侵襲 / 抗酸化力 / 酸化ストレス / d-ROM / BAP / 食道癌 / 定量化

Outline of Final Research Achievements

We examined oxidative stress value (d-ROMs: Reactive Oxygen Metabolites derived compounds), quantification of the operative invasion by the antioxidant titer (BAP: Biological Antioxidant Potential).
The d-ROMs/BAP ratio was high just after the operation of the esophagectomy, laparotomy gastorectomy, pancreatoduodenectomy and 2 central segmentectomy of the liver which were one of the most invasive surgery. In the esophagectomy, the d-ROM level significantly decreased just after an operation and recovered on day one after an operation, and recoverd to a previous value on the third day .BAP of eyes, d-ROMs significantly correlated with an operative time and bleeding just after an operation on postoperative 1/3/7 day, and it was confirmed that these showed metrics of the operative invasion.

Free Research Field

手術侵襲