Identification of molecules involved in progression of prostate cancer and construction of risk prediction model using SNP array

2014 Fiscal Year Final Research Report

• Project/Area Number: 24592373
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Urology
• Research Institution: Akita University
• Principal Investigator: TSUCHIYA Norihiko 秋田大学, 医学(系)研究科(研究院), 准教授 (70282176)
• Co-Investigator(Kenkyū-buntansha): HABUCHI Tomonori 秋田大学, 大学院医学系研究科, 教授 (00293861) ; NARITA Shintaro 秋田大学, 医学部, 講師 (40396552)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 前立腺癌 / 遺伝子多型 / CYP19

Outline of Final Research Achievements

In this study, we evaluated a biological functional of the CYP19 polymorphisms. The ratio of serum estrone/ androstenedione was significantly associated with the CYP19 polymorphisms and the polymorphisms altered the promoter activity of the CYP19 gene. Additionally, the cancer-specific survival of metastatic prostate cancer patients was significantly associated with the CYP19 polymorphisms. Those finding suggest that the CYP19 polymorphisms influence the risk and outcome of prostate cancer through the alteration in sex hormone milieu.

Free Research Field

泌尿器科学