2014 Fiscal Year Final Research Report
Identification of mechanism of bladder cancer development with Ral associated molecular network
| Project/Area Number |
24592386
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Kyoto University |
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Principal Investigator |
MATSUI Yoshiyuki 京都大学, 医学(系)研究科(研究院), 講師 (00582107)
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| Co-Investigator(Kenkyū-buntansha) |
OGAWA Osamu 京都大学, 医学研究科, 教授 (90260611)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 膀胱癌 |
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| Outline of Final Research Achievements |
We recognized that the activation of Ral induced by the down-regulation of RalGAPα2 had a possibility to be related to the bladder carcinogenesis, through suppressing Filamin A expression. We confirmed that the immunostaining intensity of Filamin A in human bladder cancer tissue was correlated with pathological aggressiveness and infiltration. Suppression of Filamin A led to reduced proliferation in bladder cancer cell lines, whereas we did not observe significant changes in cell migration and invasion. Filamin A did not affect the tumor growth and local invasion ability in subcutaneous and renal subcapsular xenograft models.
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| Free Research Field |
膀胱癌
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