2014 Fiscal Year Final Research Report
Roles of mammalian cold shock proteins in spermatogenesis
| Project/Area Number |
24592446
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Urology
|
|---|
| Research Institution | Kyoto University |
|---|
Principal Investigator |
FUJITA JUN 京都大学, 医学(系)研究科(研究院), 教授 (50173430)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
NISHIYAMA Hiroyuki 筑波大学, 医学医療系, 教授 (20324642)
|
|---|
| Project Period (FY) |
2012-04-01 – 2015-03-31
|
| Keywords | ストレス応答 / 精巣 / 炎症 / 体内時計 / 発がん |
|---|
| Outline of Final Research Achievements |
To clarify the functions of the cold shock protein Cirp in vivo, we produced cirp-knockout mice. We found that Cirp facilitates proliferation of undifferentiated. spermatogonia by inhibiting Dyrk1b. Cirp confers robustness to circadian oscillators through regulation of Clock expression. CIRP functions extracellularly as well and is a damage-associated molecular pattern molecule that promotes inflammatory responses in shock and sepsis. Cirp promotes the development of inflammation and carcinogenesis in liver and colon through regulating apoptosis and production of cytokines in inflammatory cells.
Thus, Cirp has both beneficial and detrimental effects in vivo.
|
| Free Research Field |
分子医学
|
