2015 Fiscal Year Final Research Report
The elucidate of dynamics after the transplant of the freeze culture mucosa using oral mucosa epithelium progenitor / stem cells
| Project/Area Number |
24593051
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Niigata University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
YOSHIZAWA Michiko 新潟大学, 医歯学総合病院, 講師 (60303137)
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Keywords | 組織工学 / 凍結培養粘膜 / 口腔粘膜上皮前駆/幹細胞 |
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| Outline of Final Research Achievements |
The aim of this study was to elucidae of dynamics after the transplant of more active high freeze cultured cell mucosa, we manufactured culture composition oral mucosa using the culture epithelial cells of filtering group and the group which did not perform it for theand obtained a transplant part tissue of each group after transplant, transplant in nude mouse subcutis on 1, 10, 28 day on day 11 after cellular dissemination and were histologic and evaluated it immunohistologically. The cells that filtering (+) group was more uniform as for the form of cells than a filtering (-) group were confirmed. Also, hyperplasy of the capillary around the neovascularisation in AlloDerm and the epithelium-rich the granulation tissue was more remarkable over time than a filtering (-) group in filtering (+) group.
Freeze EVPOME of the filtering (+) group was thought to have higher activity than the thing of the filtering (-) group than the above.
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| Free Research Field |
生物系 医歯薬学 外科系歯学
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