2014 Fiscal Year Final Research Report
Development of a treatment model for osteoporosis using an inner bone environment system
| Project/Area Number |
24593054
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Okayama University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TSUJIGIWA Hidetsugu 岡山理科大学, 理学部, 教授 (70335628)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 骨 / 骨粗鬆症 / 間葉系幹細胞 |
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| Outline of Final Research Achievements |
Our 3-year research study described that (1) CD34+, c-kit+, Sca1+ mesenchymal stem cells were easy to be differentiated to bone like cells. (2) Most suitable conditions for making beta-TCP as a mesenchymal stem cells scaffold were 1200C calcination temperature and through-holes structure with diameters of 300 micro-m. (3) Results from the study of our inner bone environments system showed that T cells especially gamma-delta T cells were affected by anti-osteoporosis drug and this mechanism may be explained by the Wnt10b cell signaling.
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| Free Research Field |
外科系歯学
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