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2014 Fiscal Year Final Research Report

Involvoment of satellite glial cells in trigeminal ganglion in tongue pain

Research Project

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Project/Area Number 24593064
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Surgical dentistry
Research InstitutionNihon University

Principal Investigator

SHINODA Masamichi  日本大学, 歯学部, 准教授 (20362238)

Co-Investigator(Kenkyū-buntansha) IWATA Koichi  日本大学, 歯学部, 教授 (60160115)
ASANO Masatake  日本大学, 歯学部, 准教授 (10231896)
TANABE Natsuko  日本大学, 歯学部, 准教授 (10409097)
Co-Investigator(Renkei-kenkyūsha) SUZUKI Ikuko  日本大学, 歯学部, 助手 (60459906)
HONDA Kuniya  日本大学, 歯学部・ポスト・ドクトラル, フェロー (20548945)
OMAGARI Daisuke  日本大学, 歯学部, 専修研究員 (10608699)
Project Period (FY) 2012-04-01 – 2015-03-31
Keywords舌痛症 / TRPV1 / Artemin / 熱痛覚過敏 / satellite cell / GAP43 / GFAP / TLR4
Outline of Final Research Achievements

Burning mouth syndrome is characterized by altered sensory qualities, namely tongue pain hypersensitivity. We found that the mRNA expression of Artemin (Artn) in the tongue mucosa of burning mouth syndrome patients was significantly higher than that of control subjects, and we developed a mouse model of burning mouth syndrome by application of 2,4,6-trinitrobenzene sulfonic acid (TNBS) to the dorsum of the tongue. TNBS application to the tongue induced persistent, week-long non-inflammatory tongue pain and a significant increase in Artn expression in the tongue mucosa and marked tongue heat hyperalgesia whichwas inhibited by local administration of neutralizing anti-Artn antibody. These results suggest that the overexpression of Artn in the TNBS-treated tongue increases the membrane excitability of TG neurons innervating the tongue by increasing TRPV1 sensitivity, which causes heat hyperalgesia.

Free Research Field

口腔生理学

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Published: 2016-06-03  

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