Usefulness of the complex consisting of three regenerative factors, which can be processed and shaped in vitro for regeneration of severely destructed periodontal tissues

2014 Fiscal Year Final Research Report

• Project/Area Number: 24593122
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Periodontal dentistry
• Research Institution: Hiroshima University
• Principal Investigator: SHIBA Hideki 広島大学, 医歯薬保健学研究院(歯), 教授 (60260668)
• Co-Investigator(Kenkyū-buntansha): FUJITA Tsuyoshi 広島大学, 病院, 講師 (80379883) ; TAKEDA Katsuhiro 広島大学, 大学院医歯薬保健学研究院, 助教 (10452591)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 歯周療法学 / 歯周組織再生 / 幹細胞 / 細胞外基質 / LL37 / 再生3要素

Outline of Final Research Achievements

We developed the ball-shaped mesenchymal stem cell complex (B-MSC) which contains bone marrow-derived MSC, self-produced extracellular matrices and no artificial scaffold, and which can be processed in vitro. Furthermore, the osteogenic-differentiated B-MSC and the synthesized LL37 which increases the production of vascular endothelial growth factor enhanced bone regeneration in the rat calvarial defect model. Therefore, the transplantation of B-MSC and LL37 may represent a novel tissue engineering therapy for regeneration of periodontal tissues (bone).

Free Research Field

歯周療法学