The role of IL-35 on Th17 cells in inflamed gingiva

2014 Fiscal Year Final Research Report

• Project/Area Number: 24593134
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Periodontal dentistry
• Research Institution: Aichi Gakuin University
• Principal Investigator: MITANI Akio 愛知学院大学, 歯学部, 教授 (50329611)
• Co-Investigator(Kenkyū-buntansha): KIKUCHI Takeshi 愛知学院大学, 歯学部, 講師 (40421242) ; AINO Makoto 愛知学院大学, 歯学部, 助教 (20572811) ; ISHIHARA Yuichi 松本歯科大学, 歯学部, 教授 (50261011)
• Research Collaborator: FUJIMURA Takeki 愛知学院大学, 歯学部, 助教 (40749892)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: IL-35 / 歯周組織 / Th17 / 歯学 / 免疫学

Outline of Final Research Achievements

IL-17- and IL-35-related gene expressions in gingiva and that protein levels in GCF were higher in patients with chronic periodontitis compared to the healthy group. There was a tendency toward a negative correlation between IL-17 and IL-35 in GCF samples; however, this was not significant. Furthermore, rIL-35 inhibited the Th17-related genes expression and IL-17 protein production in Th17 cells. These results suggest that IL-35 may directly act to the Th17 cells, and followed by inhibition of the IL-17 production.
Taken together, IL-35 might play a suppressive role in periodontal disease by inhibition of IL-17 production from Th17 cells in order to suppress excessive inflammation in gingiva.

Free Research Field

医歯薬学