Toward the application of MK 615 to dental medicine:Analysis of anti-caries · anti-periodontal disease characteristics

2016 Fiscal Year Final Research Report

• Project/Area Number: 24593161
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Social dentistry
• Research Institution: Kagoshima University
• Principal Investigator: Morimoto Yoko 鹿児島大学, 医歯学域附属病院, 助教 (30437967)
• Project Period (FY): 2012-04-01 – 2017-03-31
• Keywords: MK615 / 抗炎症 / 抗菌 / 骨破壊抑制

Outline of Final Research Achievements

This study examined whether plum meat extract, which is known to contribute to health promotion since ancient times, is effective for dental caries and periodontal disease treatment and prevention. Inflammatory cytokines produced from gingival tissue cells stimulated with LPS in the periodontal pathogenic bacteria has been shown to be significantly suppressed by the addition of plum extract MK615. In addition, MK 615 was shown to suppress bone destruction due to periodontal disease by suppressing the maturation of osteoclasts. Furthermore, it was shown that proliferation of dental caries-related bacteria and periodontal pathogenic bacteria can be suppressed significantly by adding MK615. From these facts, it was suggested that Plum Meat Extract Extract MK 615 is effective for anti-caries and anti-periodontal disease.

Free Research Field

歯科保存学 歯周病治療学