2014 Fiscal Year Final Research Report
The efficacy of olfactory mucosa as a source of neural stem cells
| Project/Area Number |
24615008
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Regenerative medicine
|
|---|
| Research Institution | Kawasaki Medical School |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
HIMI Naoyuki 川崎医科大学, 医学部, 講師 (70412161)
OKABE Naohiko 川崎医科大学, 医学部, 助教 (30614276)
NARITA Kazuhiko 川崎医科大学, 医学部, 講師 (60104808)
|
|---|
| Research Collaborator |
MARUYAMA Emi
AUER Roland N
|
|---|
| Project Period (FY) |
2012-04-01 – 2015-03-31
|
| Keywords | 嗅粘膜 / 神経幹細胞 / 嗅神経鞘細胞 / 移植 / 難治性てんかん / パーキンソン病 |
|---|
| Outline of Final Research Achievements |
The efficacy of olfactory mucosa as a source of neural stem cells was investigated. Stem cells of olfactory epithelium were differentiated into neural cells by adding neurotrophic factors such as BDNF and GDNF to culture medium. On the other hand, olfactory ensheathing cells (OECs) were abundant in lamina propria and cultured until 70% confluent. We transplanted both neural stem cells and OECs into intractable epilepsy or Parkinson model rats. Behavioral abnormality were improved in Parkinson rats but not in epilepsy rats. The results suggest that olfactory mucosa is useful as a cellular reservoir for transplantation.
|
| Free Research Field |
神経生理
|
