Regulation of IgA responses against influenza virus

2014 Fiscal Year Final Research Report

• Project/Area Number: 24659029
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Biological pharmacy
• Research Institution: St. Luke's International University (2014); The University of Tokyo (2012-2013)
• Principal Investigator: IRIMURA Tatsuro 聖路加国際大学, その他部局等, その他 (80092146)
• Co-Investigator(Renkei-kenkyūsha): HASEGAWA Hideki 国立感染症研究所, 感染病理部, 部長 (30301790) ; AINAI Akira 国立感染症研究所, インフルエンザ研究センター, 研究員 (10572133) ; DENDA Kaori 聖路加国際大学, 研究センター, 上級研究院 (00313122)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: レクチン / インフルエンザ / 樹状細胞 / 免疫ノグロブリン

Outline of Final Research Achievements

The aim of this study is to elucidate whether MGL2 is involved in the immune response against influenza virus, particularly IgA responses, in the airway using mice. Mouse-adapted influenza strain, PR8, was administrated into the airways of MGL2-KO and wild-type mice and pathogenesis, cytokine production, and immunoglobulin production were investigated. There was no remarkable differences in MGL2-KO mice. However, in the skin, dendritic cells expressing MGL2 were proven to be responsive for skewing the response toward the Th2-type.

Free Research Field

免疫学、糖鎖生物学