2013 Fiscal Year Final Research Report
Medium-to-small vessel vasculitis induced by NKT cells that react with vascular endothelial cells
| Project/Area Number |
24659171
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Experimental pathology
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| Research Institution | Hokkaido University |
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Principal Investigator |
ISHIZU Akihiro 北海道大学, 保健科学研究院, 教授 (60321957)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 血管炎 / 血管内皮細胞 / 自己免疫 / NKT細胞 |
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| Research Abstract |
A T cell clone reactive with rat vascular endothelial cells (REC) was established from the rat model of medium-to-small vessel vasculitis and named VASC-1. Intravenous injection of VASC-1 induced small vessel vasculitis (SVV) in normal recipients. After interaction with REC, several cytokines were produced from VASC-1, which was inhibited by blocking of CD1d on the REC surface. The collective findings indicated VASC-1 as an NKT cell clone. NKT cells are classified into type I and II. Type I NKT cells are characterized by expression of semi-invariant TCRs and potential to bind to marine sponge-derived alpha-galactosylceramide (a-GalCer) loaded on CD1d; whereas, type II NKT cells do not manifest the characteristics. VASC-1 exhibited a usage of TCR other than the type I invariant TCR and did not bind to a-GalCer-loaded CD1d; therefore, it was regarded as a type II NKT cell clone. These evidences suggested that REC-reactive type II NKT cells could be involved in the pathogenesis of SVV.
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[Journal Article] Prediction of response to treatment by gene expression profiling of peripheral blood in patients with microscopic polyangiitis. (for JMAAV)2013
Author(s)
Ishizu A, Tomaru U, Murai T, Yamamoto T, Atsumi T, Yoshiki T, Yumura W, Yamagata K, Yamada H, Kumagai S, Kurokawa MS, Suka M, Makino H, Ozaki S
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Journal Title
PLoS One
Volume: 8(5)
Pages: e63182
DOI
Peer Reviewed
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[Journal Article] Severity-based treatment for Japanese patients with MPO-ANCA-associated vasculitis : the JMAAV study2012
Author(s)
Ozaki S, Atsumi T, Hayashi T, Ishizu A, Kobayashi S, Kumagai S, Kurihara Y, Kurokawa MS, Makino H, Nagafuchi H, Nakabayashi K, Nishimoto N, Suka M, Tomino Y, Yamada H, Yamagata K, Yoshida M, Yumura W.
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Journal Title
Mod Rheumatol
Volume: 22(3)
Pages: 394-404
DOI
Peer Reviewed
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[Presentation] Prediction of prognosis by gene expression profiling of peripheral blood in Japanese patients with MPO-ANCA-associated vasculitis after standard treatment : JMAAV subanalysis2012
Author(s)
Ishizu A, Tomaru U, Murai T, Yamamoto T, Yoshiki T, Yumura W, Yamagata K, Yamada H, Kumagai S, Kurokawa MS, Suka M, Makino H, Ozaki S.
Organizer
The Asia Pacific Meeting of Vasculitis and ANCA Workshop 2012
Place of Presentation
Shinagawa, Tokyo, Japan
Year and Date
20120328-31
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