2014 Fiscal Year Final Research Report
Sphingolipid metabolism in thrombosis and hemostasis
| Project/Area Number |
24659469
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Hematology
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| Research Institution | Sojo University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MIYAHARA Kohji 崇城大学, 生物生命学部, 准教授 (40325155)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | スフィンゴミエリン / スフィンゴ脂質 / セラミド / スフィンゴミエリン合成酵素 / スフィンゴシン1-リン酸 / S1Pリアーゼ / スフィンゴミエリナーゼ / 線虫 |
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| Outline of Final Research Achievements |
Sphingolipids are important components of cellular membranes and act as signaling molecules such as ceramide and sphingosine 1-phosphate, potentially regulating cellular processes such as growth, differentiation, adhesion, migration, autophagy, and apoptosis. Here, we have investigated the biological function of sphingolipid metabolic enzymes by using mice and C. elegans mutants deficient for these enzymes.
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| Free Research Field |
分子細胞生物学
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