2013 Fiscal Year Final Research Report
Pathophysiological Roles of AdipoR1/AdipoR2 in the Prevention of Atherosclerosis
| Project/Area Number |
24790908
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Metabolomics
|
|---|
| Research Institution | The University of Tokyo |
|---|
Principal Investigator |
IWABU Miki 東京大学, 医学部附属病院, 特任助教 (70392529)
|
|---|
| Project Period (FY) |
2012-04-01 – 2014-03-31
|
| Keywords | アディポネクチン / アディポネクチン受容体 / 動脈硬化 / マクロファージ / 血管 |
|---|
| Research Abstract |
The adipocyte-derived hormone adiponectin has been proposed to play the central roles as antidiabetic and antiatherogenic adipokine. However, whether adiponectin receptors AdipoR1 and AdipoR2 have the protective roles against atherosclerosis in vivo are still undetermined.Therefore, in this study we investigated the in vivo roles of AdipoR1 and AdipoR2 on atherosclerosis using conventional or tissue-specific AdipoR1 and/or AdipoR2 knockout or transgenic mice as well as transplantation of bone marrow from AdipoR knockout mice.
This study provides the direct evidence that AdipoR2 in endothelial cells and AdipoR1 in macrophages play protective roles against atherosclerosis in vivo.
|
-
-
-
[Journal Article] A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity2013
Author(s)
Okada-Iwabu M, Yamauchi T, Iwabu M, Honma T, Hamagami K, Matsuda K, Yamaguchi M, Tanabe H, Kimura-Someya T, Shirouzu M, Ogata H, Tokuyama K, Ueki K, Nagano T, Tanaka A, Yokoyama S and Kadowaki T
-
Journal Title
Nature
Volume: 503
Pages: 493-498
DOI
Peer Reviewed
-
-
-
[Journal Article] A single nucleotide polymorphism in ANK1 is associated with susceptibility to type 2 diabetes in Japanese populations2012
Author(s)
Imamura M, Maeda S, Yamauchi T, Hara K, Yasuda K, Morizono T, Takahashi A, Horikoshi M, Nakamura M, Fujita H, Tsunoda T, Kubo M, Watada H, Maegawa H, Okada-Iwabu M, Iwabu M, Shojima N, Ohshige T, Omori S, Iwata M, Hirose H, Kaku K, Ito C, Tanaka Y, Tobe K, Kashiwagi A, Kawamori R, Kasuga M, Kamatani N ; Diabetes Genetics Replication and Meta-analysis (DIAGRAM) Consortium, Nakamura Y and Kadowaki T
-
Journal Title
Hum Mol Genet
Volume: 21
Pages: 3042-2049
DOI
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
