2013 Fiscal Year Final Research Report
Establishment of better mouse models of Graves' disease and Grave's ophtahlmopathy
| Project/Area Number |
24790948
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Endocrinology
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| Research Institution | Nagasaki University |
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Principal Investigator |
NAKAHARA Mami 長崎大学, 原爆後障害医療研究所, 客員研究員 (90622605)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 甲状腺自己免疫 / 甲状腺刺激ホルモン受容体 |
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| Research Abstract |
(1) To determine the appropriate amounts of adenovirus, various amounts of adenovirus were used to immunize mice, revealing that the lower amounts of virus induced higher titers of TSAb and hyperthyroidism, the latter, however, did not last long. (2) Naturally occurring or immunization-induced Graves disease was not observed in mice generated by using SKG and ZAP-70 KO mice having various levels of defects in the signal transduction pathway in T lymphocytes. (3) Experiments of immunization of mice with TSHR + calsequestrin or collagen XIII plus exposure to cigarette smoke revealed that cigarette smoke exacerbated macrophage infiltration in the orbits.
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Research Products
(6 results)
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[Journal Article] Postnatal expression of BRAFV600E does not induce thyroid cancer in mouse models of thyroid papillary carcinoma2013
Author(s)
Shimamura M, Nakahara M, Orim F, Kurashige T, Mitsutake N, Nakashima M, Kondo S, Yamada M, Taguchi R, Kimura S, Nagayama Y
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Journal Title
Endocrinology
Volume: 154(11)
Pages: 4423-4430
DOI
Peer Reviewed
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