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2013 Fiscal Year Final Research Report

The role of citric acid cycle and related metabolites in IDH1-mutated gliomas

Research Project

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Project/Area Number 24791490
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Cerebral neurosurgery
Research InstitutionKanazawa University

Principal Investigator

WATANABE Takuya  金沢大学, 医学系, 協力研究員 (90399775)

Project Period (FY) 2012-04-01 – 2014-03-31
Keywords神経膠腫 / IDH1 / クエン酸サイクル / MRS / 免疫組織化学
Research Abstract

We analyzed the intratumoral metabolism of 19 glioma samples using the LC model that the third party software which can calculate quantitative MR spectrum value of each metabolites. We especially focused on citric acid related metabolites including N-acetyl-aspartate (NAA) and N-acetyl-aspartyl-glutamate (NAAG). Major metabolites in glial cells such as glucose, glutamate acid, GPC did not indicate significant change between IDH-mutated and wild-type glioma. NAA also did not indicate significant differences, whereas NAAG indicated 0.237 (35% reduction) in IDH-mutated glioma comparison to 0.362 in wild type glioma, suggesting that metabolic environment in glioma cells were significantly changed between IDH-mutated and wild-type glioma. Pre-operative MR analysis of glioma using LC model has the possibility of differential diagnosis of IDH-mutated glioma.

  • Research Products

    (19 results)

All 2014 2013 2012

All Journal Article (11 results) (of which Peer Reviewed: 11 results) Presentation (7 results) Book (1 results)

  • [Journal Article] Prognostic paradox : brain damage around the glioblastoma resection cavity2014

    • Author(s)
      Furuta T, Nakada M, Ueda F, Watanabe T, Arakawa Y, Higashi R, Hashimoto M, Nitta H, Hayashi Y, Hamada
    • Journal Title

      JI.J Neurooncol

      Volume: (Epub ahead of print)

    • Peer Reviewed
  • [Journal Article] The mechanism of chemoresistance against tyrosine kinase inhibitors in malignant glioma2014

    • Author(s)
      Nakada M, Kita D, Watanabe T, Hayashi Y, Hamada
    • Journal Title

      JI.Brain Tumor Pathol

      Volume: (Epub ahead of print)

    • Peer Reviewed
  • [Journal Article] Characterizing invading glioma cells based on IDH1-R132H and Ki-67 immunofluorescence2014

    • Author(s)
      Sabit H, Nakada M, Furuta T, Watanabe T, Hayashi Y, Sato H, Kato Y, Hamada
    • Journal Title

      JI.Brain Tumor Pathol

      Volume: (Epub ahead of print)

    • Peer Reviewed
  • [Journal Article] Receptor tyrosine kinases : principles and functions in glioma invasion2013

    • Author(s)
      Nakada M, Kita D, Teng L, Pyko IV, Watanabe T, Hayashi Y, Hamada
    • Journal Title

      J.Adv Exp Med Biol

      Volume: 986(Review) Pages: 143-70

    • Peer Reviewed
  • [Journal Article] Right superior longitudinal fasciculus : implications for visuospatial neglect mimicking Gerstmann's syndrome2013

    • Author(s)
      Hayashi Y, Kinoshita M, Furuta T, Watanabe T, Nakada M, Hamada J
    • Journal Title

      Clin Neurol Neurosurg

      Volume: 115(6) Pages: 775-7

    • Peer Reviewed
  • [Journal Article] Visualization of angiographical arteriovenous shunting in perisylvian glioblastomas2013

    • Author(s)
      Yoshikawa A, Nakada M, Kita D, Watanabe T, Kinoshita M, Miyashita K, Furuta T, Hamada JI, Uchiyama N, Hayashi Y
    • Journal Title

      Acta Neurochir (Wien)

      Volume: 155(4) Pages: 715-9

    • Peer Reviewed
  • [Journal Article] Orbital cystic schwannoma originating from the frontal nerve2012

    • Author(s)
      Hayashi Y, Watanabe T, Kita D, Hayashi Y, Takahira M, Hamada J
    • Journal Title

      Case Rep Ophthalmol Med

    • Peer Reviewed
  • [Journal Article] Neuro-Sweet disease mimicking recurrent anaplastic astrocytoma associated with therapy-related myelodysplastic syndrome : a case report2012

    • Author(s)
      Shimizu Y, Watanabe T, Nakada M, Hayashi Y, Hamaguchi Y, Sugimori N, Hamada J
    • Journal Title

      Clin Neurol Neurosurg

      Volume: 114(7) Pages: 1049-51

    • Peer Reviewed
  • [Journal Article] Progressive adult primary glioblastoma in the medulla oblongata with an unmethylated MGMT promoter and without an IDH mutation2012

    • Author(s)
      Yoshikawa A, Nakada M, Watanabe T, Hayashi Y, Sabit H, Kato Y, Suzuki S, Ooi A, Sato H, Hamada J
    • Journal Title

      Brain Tumor Pathol

      Volume: 30(3)(Review) Pages: 175-9

    • Peer Reviewed
  • [Journal Article] Association between carotid plaque composition assessed by multidetector computed tomography and cerebral embolism after carotid stenting2012

    • Author(s)
      Uchiyama N, Misaki K, Mohri M, Watanabe T, Hirota Y, Nakada M, Hayashi Y, Ueda F, Hamada J
    • Journal Title

      Neuroradiology

      Volume: 54(5) Pages: 487-93

    • Peer Reviewed
  • [Journal Article] Progressive tentorial cavernous malformation2012

    • Author(s)
      Furuta T, Nakada M, Watanabe T, Hayashi Y, Hamada J
    • Journal Title

      Surg Neurol Int

      Volume: 3 Pages: 18

    • Peer Reviewed
  • [Presentation] 高齢者中枢神経系悪性リンパ腫に対する定位放射線治療-地域環境にあわせた低侵襲治療-2013

    • Author(s)
      渡邉 卓也, 南部 育, 橋本 正明
    • Organizer
      第72回日本脳神経外科学会学術総会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2013-10-18
  • [Presentation] GSK3β 阻害作用を有する既存薬剤を用いた再発膠芽腫治療の第I・II 相臨床試験における患者背景とバイオマーカーに関する検討2013

    • Author(s)
      宮下 勝吉, 中田光俊, 林 裕, 渡邉卓也, 木下 雅史, 田中 慎吾, 古田拓也, 淑瑠ヘムラサビット, 喜多 大輔, 源 利成, 濵田 潤一郎
    • Organizer
      第72回日本脳神経外科学会学術総会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2013-10-18
  • [Presentation] GSK3β 阻害作用を有する既存薬剤を用いた再発膠芽腫の免疫組織学的検討2012

    • Author(s)
      宮下勝吉, 中田光俊, 林 裕, 渡邉 卓也, 古田 拓也, 淑瑠 ヘムラサビット, 源 利成, 濵田 潤一郎
    • Organizer
      第30回日本脳腫瘍学会学術集会
    • Place of Presentation
      グランドプリンスホテル広島
    • Year and Date
      2012-11-27
  • [Presentation] IDH 変異型神経膠腫の画像診断の試み2012

    • Author(s)
      渡邉 卓也, 中田 光俊, 油野 裕之, 植田 文明, 淑瑠 ヘムラサビット, 北林 朋宏, 橋本正明, 林 裕, 濱田 潤一郎
    • Organizer
      第30回日本脳腫瘍学会学術集会
    • Place of Presentation
      グランドプリンスホテル広島
    • Year and Date
      2012-11-26
  • [Presentation] LC model MR Spectroscopy による IDH変異型神経膠腫の画像診断の試み2012

    • Author(s)
      渡邉 卓也, 中田 光俊, 油野 裕之, 植田 文明, 淑瑠 ヘムラサビット, 北林 朋宏, 橋本正明, 林 裕, 濱田 潤一郎
    • Organizer
      第71回日本脳神経外科学会学術総会
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2012-10-19
  • [Presentation] 絶対定量プロテオミクスによる膠芽腫の蛋白発現プロファイリンクとテーラーメイト分子標的療法の提唱2012

    • Author(s)
      中田 光俊, 林 裕, 小渕 航, 大槻 純男, 古田 拓也, 木下 雅史, 渡邉 卓也, 田中 慎吾, 宮下 勝吉, 喜多 大輔, 淑瑠 ヘムラサビット, 毛利 正直, 林 康彦, 内山 尚之, 寺崎 哲也, 濱田 潤一郎
    • Organizer
      第71回日本脳神経外科学会学術総会
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2012-10-17
  • [Presentation] IDH1 免疫組織化学による浸潤グリオーマ細胞の検討2012

    • Author(s)
      淑瑠 ヘムラサビット, 中田 光俊, 渡邉 卓也, 林 裕, 加藤 幸成, 佐藤 博, 濵田 潤一郎
    • Organizer
      第30回日本脳腫瘍病理学会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2012-05-25
  • [Book] Advances in experimental medicine and biology, chapter 8, Receptor Tyrosine Kiases: Principles and Functions in Glioma Invasion2013

    • Author(s)
      Mitsutoshi Nakada, Daisuke Kita, Takuya Watanabe, Yutaka Hayashi, Jun-ichiro Hamada
    • Total Pages
      143-170(986)
    • Publisher
      Science+Buisiness Media Dordrecht

URL: 

Published: 2015-06-25  

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