2014 Fiscal Year Final Research Report
Molecular analysis of the molecular target drugs in brain tumors.
| Project/Area Number |
24791511
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Oita University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
|
| Keywords | 神経膠芽腫 / 浸潤 / 分子標的薬剤 |
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| Outline of Final Research Achievements |
Glioblastoma multiforme (GBM) is the most invasive form in gliomas and extremely refractory to therapy. An investigation of the molecules regulating invasion will thus contribute to the GBM treatment. We have previously shown that GEP100 plays an important role in the invasive activities of human breast cancer. The GEP100, activated by receptor tyrosine kinases, appears to be common in angiogenesis and cancer invasion.
We here found that GEP100 is highly expressed in GBM cell lines correlated with invasive activity, and GEP100 tend to be expressed with RTK in GBM by immune-histochemical analysis. Our results indicate that GEP100 is one of the major components of GBM invasion.
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| Free Research Field |
医歯薬学
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