Study for a new treatment for retinitis pigmentosa

2013 Fiscal Year Final Research Report

• Project/Area Number: 24791850
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Ophthalmology
• Research Institution: Kyoto University
• Principal Investigator: IKEDA Hanako 京都大学, 医学(系)研究科(研究院), 助教 (20372162)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Keywords: 神経保護 / 網膜色素変性

Research Abstract

We tried if VCP ATPase inhibitors would be a new treatment for retinitis pigmentosa. rd10, a model mouse for retinitis pigmentosa and rabbits having the mutated rhodopsin gene were used to try the neuroprotective effect of the inhibitors. In these animals, thickness of the retina was larger in the treated animals than in the non-treated ones. b-wave amplitudes of electroretinogram in the treated animals were larger than those in the non-treated animals. In rd12 mice, VCP ATPase inhibitors were administered after the age of 12 months, when the disease had progressed. In the elder rd12 mice, the thickness of the retina and the amplitudes of the b-wave were larger in the treated than in the non-treated mice. The newly synthesized VCP ATPase inhibitors would be a new neuroprotective treatment for retinitis pigmentosa.

Research Products

• [Journal Article] Imaging of localized retinal nerve fiber layer defects in preperimetric glaucoma using spectral-domain optical coherence tomography (2014)
  • Author(s): Nukada, M., Hangai, M., Mori, S., Takayama, K., Nakano, N., Morooka, S., Ikeda, H. O., Akagi, T., Nonaka, A. & Yoshimura, N
  • Journal Title: J Glaucoma Volume: 23 Pages: 150-159
  • DOI: 10.1097/IJG.0b013e3182707456
• [Journal Article] Paracentral scotoma in glaucoma detected by 10-2 but not by 24-2 perimetry (2014)
  • Author(s): Hangai, M., Ikeda, H. O., Akagi, T. & Yoshimura, N
  • Journal Title: Jpn J Ophthalmol Volume: 58 Pages: 188-196
  • DOI: 10.1007/s10384-013-0298-9
• [Journal Article] High-resolution imaging of retinal nerve fiber bundles in glaucoma using adaptive optics scanning laser ophthalmoscopy (2013)
  • Author(s): Takayama, K., Ooto, S., Hangai, M., Ueda-Arakawa, N., Yoshida, S., Akagi, T., Ikeda, H. O., Nonaka, A., Hanebuchi, M., Inoue, T. & Yoshimura, N
  • Journal Title: Am J Ophthalmol Volume: 155 Pages: 870-881
  • DOI: 10.1016/j.ajo.2012.11.016
• [Journal Article] Three-dimensional imaging of lamina cribrosa defects in glaucoma using swept-source optical coherence tomography (2013)
  • Author(s): Takayama, K., Hangai, M., Kimura, Y., Morooka, S., Nukada, M., Akagi, T., Ikeda, H. O., Matsumoto, A. & Yoshimura, N
  • Journal Title: Invest Ophthalmol Vis Sci Volume: 54 Pages: 4798-4807
  • DOI: 10.1167/iovs.13-11677
• [Journal Article] Macular imaging in highly myopic eyes with and without glaucoma (2013)
  • Author(s): Nakano, N., Hangai, M., Noma, H., Nukada, M., Mori, S., Morooka, S., Takayama, K., Kimura, Y., Ikeda, H. O., Akagi, T. & Yoshimura, N
  • Journal Title: Am J Ophthalmol Volume: 156 Pages: 511-523
  • DOI: 10.1016/j.ajo.2013.04.028
• [Journal Article] Macular structure parameters as an automated indicator of paracentral scotoma in early glaucoma (2013)
  • Author(s): Kimura, Y., Hangai, M., Matsumoto, A., Akagi, T., Ikeda, H. O., Ohkubo, S., Sugiyama, K., Iwase, A., Araie, M. & Yoshimura, N
  • Journal Title: Am J Ophthalmol Volume: 156 Pages: 907-917
  • DOI: 10.1016/j.ajo.2013.06.029
• [Journal Article] Peripapillary scleral deformation and retinal nerve fiber damage in high myopia assessed with swept-source optical coherence tomography (2013)
  • Author(s): Akagi, T., Hangai, M., Kimura, Y., Ikeda, H. O., Nonaka, A., Matsumoto, A., Akiba, M. & Yoshimura, N
  • Journal Title: Am J Ophthalmol Volume: 155 Pages: 927-936
  • DOI: 10.1016/j.ajo.2012.12.014
• [Journal Article] A novel method to detect local ganglion cell loss in early glaucoma using spectral-domain optical coherence tomography (2012)
  • Author(s): Takayama, K., Hangai, M., Durbin, M., Nakano, N., Morooka, S., Akagi, T., Ikeda, H. O. & Yoshimura, N
  • Journal Title: Invest Ophthalmol Vis Sci Volume: 53 Pages: 6904-6913
  • DOI: 10.1167/iovs.12-10210
• [Journal Article] Real-time imaging of rabbit retina with retinal degeneration by using spectral-domain optical coherence tomography (2012)
  • Author(s): Muraoka, Y., Ikeda, H. O., Nakano, N., Hangai, M., Toda, Y., Okamoto-Furuta, K., Kohda, H., Kondo, M., Terasaki, H., Kakizuka, A. & Yoshimura, N
  • Journal Title: PLoS One Volume: 7 Pages: e36135
  • DOI: 10.1371/journal.pone.0036135
• [Journal Article] Wide 3-dimensional macular ganglion cell complex imaging with spectral-domain optical coherence tomography in glaucoma (2012)
  • Author(s): Morooka, S., Hangai, M., Nukada, M., Nakano, N., Takayama, K., Kimura, Y., Akagi, T., Ikeda, H. O., Nonaka, A. & Yoshimura, N
  • Journal Title: Invest Ophthalmol Vis Sci Volume: 53 Pages: 4805-4812
  • DOI: 10.1167/iovs.12-9870
• [Journal Article] Retinal nerve fiber layer defects in highly myopic eyes with early glaucoma (2012)
  • Author(s): Kimura, Y., Hangai, M., Morooka, S., Takayama, K., Nakano, N., Nukada, M., Ikeda, H. O., Akagi, T. & Yoshimura, N
  • Journal Title: Invest Ophthalmol Vis Sci Volume: 53 Pages: 6472-6478
  • DOI: 10.1167/iovs.12-10319
• [Presentation] Neuroprotective effect of a valosin-containing-protein ATPase inhibitor on late-stage retinal degeneration in a mouse model (2014)
  • Author(s): Tomoko Hasegawa, Hanako O. Ikeda, Yuki Muraoka1, Akira Kakizuka, Nagahisa Yoshimura
  • Organizer: World Ophthalmology Congress 2014
  • Place of Presentation: Tokyo
  • Year and Date: 2014-04-05
• [Presentation] New neuroprotective treatment using novel VCP ATPase inhibitors for glaucoma (2013)
  • Author(s): 池田華子
  • Organizer: KU-KU symposium 2013
  • Place of Presentation: 京都
  • Year and Date: 2013-09-17
• [Presentation] 新しい神経保護剤の開発ー網膜色素変性モデル動物における VCP 阻害剤の効果 (2013)
  • Author(s): 池田華子
  • Organizer: 網膜色素変性症 ・ 医療講演会
  • Place of Presentation: 大阪
  • Year and Date: 2013-05-19
• [Presentation] A Novel Valosin-Containing Protein Inhibitor Suppresses Photoreceptor Degeneration in a Rabbit Model of Retinitis Pigmentosa (2013)
  • Author(s): Yuki Muraoka, Hanako Ohashi Ikeda, Noriko Nakano, Tomoko Hasegawa, Kondo Mineo, Hiroko Terasaki, Akira Kakizuka, Nagahisa Yoshimura
  • Organizer: ARVO (The Association for Research in Vision and Ophthalmology) Annual Meeting 2013
  • Place of Presentation: Seattle, USA
  • Year and Date: 2013-05-05
• [Presentation] Optical coherence tomography, electroretinography, and histological analysis of mouse models for retinal degeneration (2013)
  • Author(s): Tomoko Hasegawa, Hanako Ohashi Ikeda, Noriko Nakano, Yuki Muraoka, Akira Kakizuka, Nagahisa Yoshimura
  • Organizer: ARVO (The Association for Research in Vision and Ophthalmology) Annual Meeting 2013
  • Place of Presentation: Seattle, USA
  • Year and Date: 2013-05-05
• [Presentation] 網膜変性モデルマウスの光干渉断層計, 網膜電図, 組織所見の比較 (2013)
  • Author(s): 長谷川智子, 池田華子, 中野紀子, 村岡勇貴, 吉村長久
  • Organizer: 日本眼科学会117回総会
  • Place of Presentation: 東京国際フォーラム
  • Year and Date: 2013-04-05
• [Presentation] VCP 阻害剤による網膜神経保護効果のメカニズム (2013)
  • Author(s): 池田華子, 中野紀子, 村岡勇貴, 長谷川智子, 垣塚彰, 吉村長久
  • Organizer: 日本眼科学会117回総会
  • Place of Presentation: 東京国際フォーラム
  • Year and Date: 2013-04-04
• [Presentation] VCP阻害剤による新規神経保護治療 (2013)
  • Author(s): 池田華子
  • Organizer: 日本眼科学会117回総会
  • Place of Presentation: 東京国際フォーラム
  • Year and Date: 2013-04-04
• [Presentation] VCP阻害剤による新規神経保護治療 (2013)
  • Author(s): 池田華子
  • Organizer: 第17回眼科分子生物研究会
  • Place of Presentation: 静岡焼津
  • Year and Date: 2013-02-23
• [Presentation] 新しい神経保護剤の開発~網膜色素変性モデル動物における VCP 阻害剤の効果~ (2012)
  • Author(s): 池田華子
  • Organizer: 第8回JRPS 網脈絡膜変性フォーラム
  • Place of Presentation: 名古屋ミッドランドスクエア
  • Year and Date: 2012-10-07
• [Presentation] VCP阻害剤による新規神経保護治療 (2012)
  • Author(s): 池田華子, 中野紀子, 村岡勇貴, 吉村長久
  • Organizer: 第2回わかもと先進眼科医療研究会
  • Place of Presentation: 東京ロイヤルパークホテル
  • Year and Date: 2012-07-20
• [Presentation] VCP 阻害剤による網膜色素変性モデルマウスにおける神経保護効果の検討 (2012)
  • Author(s): 池田華子, 中野紀子, 村岡勇貴, 板谷正紀, 垣塚彰, 吉村長久
  • Organizer: 日本眼科学会116回総会
  • Place of Presentation: 東京国際フォーラム
  • Year and Date: 2012-04-05
• [Presentation] ウサギ網膜色素変性症モデルにおける VCP阻害剤の神経保護効果の検討 (2012)
  • Author(s): 村岡勇貴, 池田華子, 中野紀子, 板谷正紀, 近藤峰生, 寺崎浩子, 吉村長久
  • Organizer: 日本眼科学会116回総会
  • Place of Presentation: 東京国際フォーラム
  • Year and Date: 2012-04-05
• [Patent(Industrial Property Rights)] 眼疾患処置薬 (2014)
  • Inventor(s): 垣塚彰, 池田華子, 吉村長久, 村岡勇貴
  • Industrial Property Rights Holder: 国立大学法人京都大学
  • Industrial Property Rights Type: PCT出願
  • Industrial Property Number: PCT/JP2014/053898
  • Filing Date: 2014-02-19
  • Overseas