Elucidation and regulation of bi-directional changes in neuronal maturation status

2017 Fiscal Year Final Research Report

• Project/Area Number: 25242078
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Basic / Social brain science
• Research Institution: Fujita Health University
• Principal Investigator: Miyakawa Tsuyoshi 藤田保健衛生大学, 総合医科学研究所, 教授 (10301780)
• Co-Investigator(Renkei-kenkyūsha): TAKAO Keizo 生理学研究所, 行動代謝分子解析センター, 特任准教授 (80420397) ; Ohira Koji 藤田保健衛生大学, 総合医科学研究所, 講師 (80402832) ; Hagihara Hideo 藤田保健衛生大学, 総合医科学研究所, 助教 (80514504) ; Koshimizu Hisatsugu 藤田保健衛生大学, 総合医科学研究所, 助教 (10610842) ; UMEMORI Juzoh 藤田保健衛生大学, 総合医科学研究所, 助教 (20462913)
• Project Period (FY): 2013-10-21 – 2018-03-31
• Keywords: 非成熟歯状回 / バイオインフォマティクス / 網羅的行動解析

Outline of Final Research Achievements

Previously we identified the “immature dentate gyrus (iDG),” a brain endophenotype shared in animal models of several psychiatric disorder, including schizophrenia and bipolar disorder. In this study, we sought to elucidate the mechanism of bi-directional changes in neuronal maturation status, and to develop the method for manipulation of maturation status, by using various cutting-edge technologies. We identified gene sets potentially involved in the development of iDG, by informatics analysis. Using optogenetics, we detected the condition under which temporal de-maturation status alters to permanent de-maturation status.

Free Research Field

神経科学