Association between characteristics of current diet and onset/deterioration of non-alcoholic fatty liver disease

2015 Fiscal Year Final Research Report

• Project/Area Number: 25282029
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Eating habits
• Research Institution: Kanazawa Medical University
• Principal Investigator: TAKEUCHI Masayoshi 金沢医科大学, 総合医学研究所, 教授 (20154982)
• Co-Investigator(Kenkyū-buntansha): TAKINO Jun-ichi 広島国際大学, 薬学部, 助教 (00440529) ; TAKATA Takanobu 金沢医科大学, 総合医学研究所, 助教 (20515308) ; UEDA Tadashi 金沢医科大学, 総合医学研究所, 助教 (80151794)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 食習慣 / NAFLD / NASH / TAGE / 生活習慣病

Outline of Final Research Achievements

With the current widespread introduction of a Western lifestyle, the number of patients with nonalcoholic fatty liver disease (NAFLD) has rapidly increased, contributing to increases in the liver cancer- or cardiovascular disease-related mortality rates. However, the etiology remains to be clarified. Our previous study indicated that toxic AGEs (TAGE), which may be primarily involved in lifestyle-related diseases (LSRD), were synthesized in vivo in the presence of postprandial hyperglycemia or after the excessive ingestion of fructose and dietary AGEs.
This study showed that the characteristics of the current diet (excessive ingestion of glucose/fructose/high-AGE drinks or foods) promoted the generation/accumulation of TAGE in hepatocytes or myocardial cells, closely contributing to the onset/deterioration of each condition, and that the blood TAGE level reflected the grade of the condition. Therefore, the results of this study may promote new strategies to prevent LSRD.

Free Research Field

生活習慣病と毒性終末糖化産物（toxic AGEs, TAGE）