2017 Fiscal Year Final Research Report
Analysis of transgenic rats prone to brain tumors.
| Project/Area Number |
25290017
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | Gunma University |
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Principal Investigator |
YOKOO HIDEAKI 群馬大学, 大学院医学系研究科, 教授 (40282389)
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| Co-Investigator(Kenkyū-buntansha) |
佐々木 惇 埼玉医科大学, 医学部, 教授 (80225862)
伊古田 勇人 群馬大学, 大学院医学系研究科, 准教授 (90420116)
信澤 純人 群馬大学, 大学院医学系研究科, 助教 (80635318)
村上 孝 埼玉医科大学, 医学部, 教授 (00326852)
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| Co-Investigator(Renkei-kenkyūsha) |
SUGAWARA Kenichi 琉球大学, 医学部, 講師 (50375573)
YOSHIMOTO Yuya 群馬大学, 重粒子線医学推進機構, 助教 (80594390)
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| Research Collaborator |
OHGAKI Hiroko
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| Project Period (FY) |
2013-04-01 – 2018-03-31
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| Keywords | 脳腫瘍 / グリオーマ / 疾患モデル動物 |
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| Outline of Final Research Achievements |
Glioblastoma is one of common brain tumors and its clinical outcome is usually miserable. Glioblastoma often shows abnormal activation of epidermal growth factor receptor (EGFR) signaling pathway, and the abnormality is believed to be closely linked to tumorigenesis. We developed a novel strain of transgenic rats designed to show constitutional overexpression of v-erbB, a viral homolog of EGFR, and the rat was demonstrated to give rise to brain tumors spontaneously after long-term latency. We performed various experiments using the model rats, together with diversified analyses human brain tumors, and obtained several curious results.
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| Free Research Field |
病理学
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