Analysis of transformation processes by using the "two-hit leukemogenesis model"

2015 Fiscal Year Final Research Report

• Project/Area Number: 25290047
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Tumor biology
• Research Institution: Miyagi Prefectural Hospital Organization Miyagi Cancer Center
• Principal Investigator: Sugamura Kazuo 地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所), その他部局等, その他 (20117360)
• Co-Investigator(Kenkyū-buntansha): SASAKI OSAMU 宮城県立がんセンター研究所, 発がん制御研究部, 特任研究員 (40538055) ; KAZUNORI YAMAGUCHI 宮城県立がんセンター研究所, 発がん制御研究部, 上席主任研究員 (80373215)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 白血病 / 免疫不全マウス

Outline of Final Research Achievements

To identify a molecule which plays a role in the initiation or malignant transformation of leukemia, we established leukemia stem cell-like cells from leukemia-derived cell lines which show high tumorigenicity in NOG mice. Micro array analysis and RNA-seq analysis revealed the aberrant expression patterns of CADM1 and CA9 genes, both of which encode cell surface proteins. Further analysis on these molecules indicated unveiled molecular mechanisms underlying tumorigenicity of leukemia cells. Our results help understanding malignant transformation of leukemia cells and suggest new possible targets for the leukemia intervention.

Free Research Field

血液腫瘍