Global search for molecular target in translocation associated and non-translocation associated soft tissue sarcoma

2016 Fiscal Year Final Research Report

• Project/Area Number: 25293088
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Human pathology
• Research Institution: Kyushu University
• Principal Investigator: ODA YOSHINAO 九州大学, 医学研究院, 教授 (70291515)
• Co-Investigator(Kenkyū-buntansha): 孝橋 賢一 九州大学, 医学(系)研究科(研究院), 講師 (10529879) ; 山元 英崇 九州大学, 大学病院, 准教授 (30404073)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Keywords: 軟部肉腫 / 染色体転座 / キメラ遺伝子 / 分子標的 / シグナル伝達 / 癌精巣抗原 / FOXM1

Outline of Final Research Achievements

In solitary fibrous tumor, activation of several tyrosin kinase receptors and signal pathways were suggested to be correlated with tumor progression and proliferation. In recently identified translocation associated soft tissue tumors, such as angiofibroma of soft tissue and CIC-DUX4/BCOR-CCNB3 positive sarcoma, detailed clinicopathological and immunohistochemical features were elucidated. The expression of transcription factor, FOXOM1, had correlation with histological grade, poor prognosis and anti-tumor drug resistance in several kinds of soft tissue sarcomas including synovial sarcoma, rhabdomyosarcoma, leiomyoma and angiosarcoma. FOXM1 may be potential molecular target in these sarcomas. In synovial sarcoma and myxoid liposarcoma, cancer-testis antigen, NY-ESO-1 and PRAME were frequently expressed. This results is suggestive that NY-ESO-1 and PRAME may be effective immunotherapy target in synovial sarcoma and myxoid liposarcoma.

Free Research Field

医歯薬学