Associations between genetic alcohol sensitivity and mental disorders

2015 Fiscal Year Final Research Report

• Project/Area Number: 25293153
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Hygiene and public health
• Research Institution: Wakayama Medical University
• Principal Investigator: Yoshimasu Kouichi 和歌山県立医科大学, 医学部, 准教授 (40382337)
• Co-Investigator(Kenkyū-buntansha): MIYASHITA Kazuhisa 和歌山県立医科大学, 医学部, 教授 (50124889) ; TAKEMURA Shigeki 和歌山県立医科大学, 医学部, 助教 (70511559) ; TSUNO Kanami 和歌山県立医科大学, 医学部, 助教 (30713309) ; TAKESHITA Tatsuya 和歌山県立医科大学, 医学部, 教授 (20150310) ; MURE Kanae 和歌山県立医科大学, 医学部, 准教授 (90268491)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 遺伝子多型 / アルコール感受性 / 精神障害 / うつ病 / 人種間比較

Outline of Final Research Achievements

Associations between genetic alcohol sensitivity regulated by ADH1B and ALDH2 pormorphism, and mental disorders were examined among Japanese employees and community dwellers. In addition, somatic factors associated with depression among Russian patients with reheumatoid arthritis (RA) were explored.
Genetic alcohol sensitivity was divided into five grade according to the combination of the two enzyme genotypes. Compared to subjects with high alcohol sensitivty, those with low alcohol sensitivity had greater risk of mental disorders among the employees. On the other hand, those with a middle grade of alcohol sensitivity had the highest risk of depression among community dwellers. Among Russian patients with RA, drinking habit was associated with a rather decreased risk of depression while not statistically significant.

Free Research Field

精神保健