Development of Autologous Bitubes for CABG Constructed in the Patients

2016 Fiscal Year Final Research Report

• Project/Area Number: 25293299
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Cardiovascular surgery
• Research Institution: Kyoto Prefectural University of Medicine
• Principal Investigator: Kanda Keiichi 京都府立医科大学, 医学(系)研究科(研究院), 講師 (60295649)
• Co-Investigator(Kenkyū-buntansha): 坂井 修 京都府立医科大学, 医学(系)研究科(研究院), 助教 (10298432) ; 渡辺 太治 京都府立医科大学, 医学(系)研究科(研究院), 助教 (20448723) ; 山南 将志 京都府立医科大学, 医学部附属病院, 専攻医 (30438204) ; 中山 泰秀 国立研究開発法人国立循環器病研究センター, 生体医工学部, 室長 (50250262) ; 夜久 均 京都府立医科大学, 医学(系)研究科(研究院), 教授 (50295648) ; 田地川 勉 関西大学, 工学部, 准教授 (80351500) ; 上地 正実 麻布大学, 獣医学部, 客員教授 (90296426)
• Co-Investigator(Renkei-kenkyūsha): Oba Kenkichi 関西大学, 名誉教授 (30029186)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Keywords: 生体内組織工学 / 小口径代用血管 / 冠動脈バイパス術 / 自家移植 / 同種移植 / 異種移植

Outline of Final Research Achievements

In vivo tissue engineered vascular graft “Biotube”was optimized for the application to CABG in terms of physiological property and antithrombogenicity. They were applied to the CABG using swine model. Surgical handring and short to mid-term performance were excellent. Biotubes are expected to be applied to the high risk patients with very low regenerative potential such as elderly patients, diabetes patients, hemodialysis patients and premature infants. Therefore for further application to such patients, allogeneic Biotube transplantation derived from healthy adults is the next need. The pilot study has been started.

Free Research Field

心臓血管外科学