2015 Fiscal Year Final Research Report
Investigation of brain tumor derived exosomes; the role in tumorigeneity and therapy
| Project/Area Number |
25293311
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurosurgery
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
YOSHIMOTO KOJI 九州大学, 大学病院, 講師 (70444784)
AMANO TOSHIYUKI 九州大学, 医学(系)研究科(研究院), 研究員 (70448413)
NAKAMIZO AKIRA 九州大学, 医学(系)研究科(研究院), 研究員 (80529800)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | glioma / exosome / microRNA / 分子病理学 / バイオマーカー |
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| Outline of Final Research Achievements |
Depend on recent advances in molecular pathology of human glioma, more accurate analysis is required for novel therapies. We established more precise genetic analysis by HRM and more simple evaluation method based on gene expression. The correlation between the gene expression type and microRNA (miR-9, -10b) indicated the relevance of microRNA for the mesenchymal-proneural transition. Furthermore analysis of secretory microRNA has revealed the potential role of secretory microRNA (miR-127, -145, -31) for glioms invasion. In addition, based on the expression of serum (plasma) microRNA, we identified potential novel biomarkers (miR-4530, -4294, -4534) for glioma patients.
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| Free Research Field |
Neurooncology
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