2015 Fiscal Year Final Research Report
Roles of Runx2 and Runx3 in cartilage degeneration
| Project/Area Number |
25293316
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Partial Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Orthopaedic surgery
|
|---|
| Research Institution | Jichi Medical University (2014-2015)
The University of Tokyo (2013) |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
SAITO Taku 東京大学, 医学部附属病院, 講師 (30456107)
TAKETOMI Shuji 東京大学, 医学部附属病院, 講師 (70570018)
|
|---|
| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Keywords | 整形外科学 / 変形性関節症 |
|---|
| Outline of Final Research Achievements |
We analyzed roles of transcription factor Runx2 and Runx3 in articular chondrocytes. First, we generated Runx2-flox mice, and confirmed that the gene deletion was successful. We then crossed Runx2-flox mice with cartilage-specific Cre mice, and created osteoarthritis model. Deletion of these factors modified cartilage degeneration. We analyzed the molecular mechanisms by in vitro experiments.
|
| Free Research Field |
整形外科学
|
