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2016 Fiscal Year Final Research Report

Development of alveolar bone turnover control method based on Wnt5a

Research Project

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Project/Area Number 25293423
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Orthodontics/Pediatric dentistry
Research InstitutionMatsumoto Dental University

Principal Investigator

Kobayashi Yasuhiro  松本歯科大学, 総合歯科医学研究所, 教授 (20264252)

Co-Investigator(Kenkyū-buntansha) 平賀 徹  松本歯科大学, 歯学部, 准教授 (70322170)
高橋 直之  松本歯科大学, 総合歯科医学研究所, 教授 (90119222)
山下 照仁  松本歯科大学, 総合歯科医学研究所, 准教授 (90302893)
Project Period (FY) 2013-04-01 – 2016-03-31
KeywordsWnt5a / 破骨細胞 / 骨芽細胞
Outline of Final Research Achievements

In order to shorten the treatment period of orthodontic treatment, we tried to elucidate the bone turnover control mechanism by Wnt5a, a cytokine, and to develop a method for controlling alveolar bone turnover based on it. Using genetically modified mice, we analyzed the role of Wnt5a in bone resorption and formation. Wnt5a enhanced the expression of Wnt co-receptor Lrp 5/6 and promoted osteoblast differentiation by β-catenin-dependent Wnt signaling pathway. Furthermore, Wnt5a suppressed the inhibitory action of Wnt16 in osteoclast differentiation. Osteoclast-derived factors suppressed the expression of sclerostin and promoted bone formation. Thus, these studies suggested that Wnt5a promotes bone turnover in alveolar bone tissues.

Free Research Field

歯科矯正学,生化学

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Published: 2018-03-22  

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