Influenza virus transmission, evolution and appearance of drug resistant viruses in Asia.

2015 Fiscal Year Final Research Report

• Project/Area Number: 25305014
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 海外学術
• Research Field: Virology
• Research Institution: Niigata University
• Principal Investigator: SAITO Reiko 新潟大学, 医歯学系, 教授 (30345524)
• Co-Investigator(Kenkyū-buntansha): SAITOH Akihiko 新潟大学, 医歯学系, 教授 (30531389) ; FUJII Masahiro 新潟大学, 医歯学系, 教授 (30183099) ; SHOBUGAWA Yugo 新潟大学, 医歯学系, 准教授 (30621198) ; HASEGAWA Go 新潟大学, 医歯学総合病院, 特任教授 (90251800) ; SAITO Kosuke 新潟大学, 医歯学系, 助教 (30460356)
• Research Collaborator: HIBINO Akinobu ; KONDO Hiroki ; ODAGIRI Takashi ; SUZUKI Hiroshi ; TAMURA Tsutomu ; Dapat Clyde ; Yadanar Kyaw ; Yi Yi Myint ; Nay Lin ; Htay Htay Tin ; Khin Yi OO ; Latt Latt Kyaw ; Rohaizat Mohd Hassan ; Shamsul Azhar Shah ; Nguyen Le Khanh Hang ; Nguyen Phuong Anh ; Le Quynh Mai ; Zaraket Hassan ; Dbaibo Ghassan
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: インフルエンザウイルス / サーベイランス / ミャンマー / レバノン / マレーシア / ベトナム / 遺伝子解析 / 薬剤耐性

Outline of Final Research Achievements

During the fiscal three years from 2013 to 2015, we conducted influenza virus surveillance in four countries, that is, Myanmar, Malaysia, Vietnam, and Lebanon. We collected 1820 nasopharyngeal samples from influenza-like illness patients and isolated 456 influenza virus (136 of A/H1N1pdo09, 169 of A/H3N2, and 151 of B). We estimated transmission patterns, and it turned out A/H1N1pdm09 shuttles between Asian side (Myanmar and Japan) and Europe side (Lebanon). In contrast, a new genotype in A/H3N2 appears in Myanmar a half year earlier than in Japan and Lebanon, that suggested A/H3N2 had one way transmission direction from Myanmar to Japan or to Lebanon. Type B did not show a certain geographical tendency due to fewer genetic diversity within Yamagata or Victoria lineages. We analyzed appearance of drug resistant influenza virus by the genetic marker assay for NA-H275Y and drug susceptibility test, but there was no appearance of resistant strains against neuraminidase inhibitors.

Free Research Field

公衆衛生