Investigation of psychiatric disorders as a disruption of homeostasis

2015 Fiscal Year Final Research Report

• Project/Area Number: 25350989
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Basic / Social brain science
• Research Institution: University of Toyama (2015); National Institute for Physiological Sciences (2013-2014)
• Principal Investigator: TAKAO Keizo 富山大学, 研究推進機構 研究推進総合支援センター, 教授 (80420397)
• Co-Investigator(Renkei-kenkyūsha): MIYAKAWA Tsuyoshi 藤田保健衛生大学, 総合医科学研究所, 教授 (10301780) ; YAMANAKA Akihiro 名古屋大学, 環境医学研究所, 教授 (60323292)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 行動解析 / 統合失調症 / 歯状回 / バイオインフォマティクス / 光遺伝学

Outline of Final Research Achievements

This research aimed to understand psychiatric disorders as a disruption of homeostasis, and aimed to develop methods of diagnosis and treatment of the disease. Specifically, we 1) explored treatments or drugs affecting the maturity of the hippocampal dentate gyrus, 2) screened for drug candidates that normalize the maturity of the dentate gyrus, and 3) attempted to control the maturity of the dentate gyrus using optogenetic techniques.

Free Research Field

神経科学