2015 Fiscal Year Final Research Report
Functional analysis of HLA ortholog expressed on marmoset placenta
| Project/Area Number |
25430095
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Laboratory animal science
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| Research Institution | Tokai University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
SASAKI Erika 公益財団法人実験動物中央研究所, 部長 (70390739)
SUZUKI Ryuji 独立行政法人国立病院機構(相模原病院臨床研究センター), 教授 (70373470)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | コモンマーモセット / MHC / 胎盤 / オーソログ |
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| Outline of Final Research Achievements |
The analysis of HLA-G function on pregnant immunity needs primate-based models because of the high evolution speed of MHC molecules and placenta development. We used common marmoset as a non-human primate pregnant model and analyzed the expression of human HLA ortholog and the interaction with maternal immunity. The GFP marmoset placenta developed in the wild type mother enabled to distinguish fetal and maternal tissues. The classical and non-classical marmoset MHC was identified expressed on the trophoblasts from decidua and villi. The secretion type HLA-G ortholog was not detected in the pregnant marmoset peripheral blood-derived plasma.
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| Free Research Field |
免疫学
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