Polyphenols with higher molecular weights as antitumor substances in botanical foods and crude drugs

2015 Fiscal Year Final Research Report

• Project/Area Number: 25450170
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Food science
• Research Institution: Okayama University
• Principal Investigator: Hatano Tsutomu 岡山大学, 医歯(薬)学総合研究科, 教授 (50127578)
• Co-Investigator(Kenkyū-buntansha): TAKEUCHI Yasuo 岡山大学, 大学院医歯薬学総合研究科, 教授 (00163387) ; SAKAGAMI Hiroshi 明海大学, 歯学部, 教授 (50138484)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: ポリフェノール / タンニン / 加水分解性タンニンオリゴマー / ギョリュウ科 / Tamarix nilotica / Tamarix aphylla / Tamarix tetrandra / 抗腫瘍効果

Outline of Final Research Achievements

Investigation of polyphenols with high-molecule structures isolated from plant organs and cultured shoots of Tamarix species of the family Tamaricaceae led to the isolation and structure elucidation of several new tannins. Antitumor effects of tannins and related polyphenols obtained from plants including those of Tamaricaceae, Myrtaceae, Davidiaceae, and Hamamelidaceae were examined, and several ones among them showed selective cytotoxic effects. Synthetic methods of tannin mimics were also established.

Free Research Field

生薬学・天然物化学