The role of androgen in a diet-dependent development of obesity and diabetes

2015 Fiscal Year Final Research Report

• Project/Area Number: 25450176
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Food science
• Research Institution: Osaka Prefecture University
• Principal Investigator: Harada Naoki 大阪府立大学, 生命環境科学研究科(系), 講師 (00529141)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: アンドロゲン / テストステロン / 男性ホルモン / 肥満・糖尿病 / 腸内細菌 / 脂質代謝 / 糖代謝 / 大腿筋

Outline of Final Research Achievements

In this study, we have identified an association between a high-fat diet and hypogonadism that impacts the development of obesity and fasting blood glucose levels in a castrated mouse model. The weight gain per food intake of castrated mice increased and dried fecal weight per food intake decreased in a high-fat diet-dependent manner. Fecal Firmicutes/Bacteroidetes ratio and Lactobacillus species counts increased in a high-fat diet-fed castrated mice. Antibiotic treatment did not induce obesity and high fasting blood glucose levels in castrated mice fed a high-fat diet. These results suggest that changes in gut microbiota are involved in the development of obesity triggered by hypogonadism.

Free Research Field

栄養生化学