Analysis of the relationship between the developmental disabilities in the offspring and the disturbance of the development of the brain including microglia by maternal undernutrition

2015 Fiscal Year Final Research Report

• Project/Area Number: 25460242
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General anatomy (including histology/embryology)
• Research Institution: Shiga University of Medical Science
• Principal Investigator: Udagawa Jun 滋賀医科大学, 医学部, 教授 (10284027)
• Co-Investigator(Kenkyū-buntansha): OKANO Junko 滋賀医科大学, 医学部, 准教授 (50447968) ; HAYAKAWA Takahiro 北海道大学, 医学部, 特任助教 (90415927) ; TAKEI Shiro 浜松医科大学, 医学部, 特任助教 (60398576)
• Co-Investigator(Renkei-kenkyūsha): KOJIMA Hideto 滋賀医科大学, 医学部, 教授 (00225434)
• Research Collaborator: HINO Kodai 滋賀医科大学, 大学院生 ; KIMURA Tomoko 滋賀医科大学, 医学部, 助手 (00449852) ; KANEKO Shunya 滋賀医科大学, 医学部医学科, 学生 ; HARASAWA Toshiya 滋賀医科大学, 医学部医学科, 学生 ; KONO Tadaaki 滋賀医科大学, 医学部医学科, 学生
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 胎生初期 / 低栄養ストレス / 行動異常 / 前頭前皮質

Outline of Final Research Achievements

In this study, we examined the impact of maternal undernutrition in the early pregnancy on behavior of the offspring. Maternal undernutrition led to hyperactivity and anti-anxiety-like behavior in the offspring at 8 weeks of age. The expression of the genes related to the biosynthesis of the phospholipid and the ratio of the phospholipid composition were altered in the prefrontal cortex of the undernourished group even though the level and turnover of monoamines and the distribution of the activated microglia were not changed. Recently, some studies suggest the relationship between the phospholipid and the behavior in the developmental disabilities. Taken together, alteration of the phospholipid composition in the prefrontal cortex may be one of the main causes of the abnormal behavior in the offspring, which was exposed to malnutritional stress.

Free Research Field

発生学