Regulation of Runx2 through hypixia and mTOR pathway in thyroid cancer

2015 Fiscal Year Final Research Report

• Project/Area Number: 25460415
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Human pathology
• Research Institution: University of Yamanashi
• Principal Investigator: KONDO Tetsuo 山梨大学, 総合研究部, 准教授 (30334858)
• Co-Investigator(Kenkyū-buntansha): KATOH Ryohei 山梨大学, 総合研究部, 教授 (30152755) ; NAKAZAWA Tadao 山梨大学, 総合研究部, 准教授 (10345704)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 甲状腺癌 / Runx2 / 低酸素 / 分子病理

Outline of Final Research Achievements

The mammalian runt-related transcription factor (Runx)　genes, including RUNX1 (AML1/CBFA2), RUNX2 (AML2/CBFA1) and RUNX3 (AML3/CBFA3), encode transcription factors that are master regulators of proliferation and differentiation　during embryonic development. Enhanced Runx2 is functionally linked to tumor invasion and metastasis of thyroid carcinoma by regulating EMT-related molecules, matrix metalloproteinases and angiogenic/lymphangiogenic factors. In this study, we demonstrated that hypoxic stimulation due to CoCl2 or hypoxic incubator (O2 1%) induce downregulation of Runx2 mRNA in thyroid carcinoma cell lines. Our data suggested that Runx2 is upregulated in the invasive area, while down regulated in the hypoxic area of the thyroid cancer.

Free Research Field

医歯薬学