The effects of shift work for trend of serum PSA and DHEA-S

2015 Fiscal Year Final Research Report

• Project/Area Number: 25460819
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Hygiene and public health
• Research Institution: Kanazawa Medical University
• Principal Investigator: MORIKAWA Yuko 金沢医科大学, 看護学部, 教授 (20210156)
• Co-Investigator(Kenkyū-buntansha): NAKAGAWA Hideaki 金沢医科大学, 総合医学研究所, 教授 (00097437)
• Co-Investigator(Renkei-kenkyūsha): NISHIJO Muneko 金沢医科大学, 医学部, 准教授 (40198461) ; SAKURAI Masaru 金沢医科大学, 医学部, 准教授 (90397216) ; NAKAMURA Koshi 北海道大学, 医学部, 准教授 (80422898) ; NAGASAWA Shin-ya 金沢医科大学, 医学部, 講師 (30510341)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 深夜勤務 / 交代勤務 / 前立腺 / 副腎アンドロゲン / DHEA-S / PSA / 加齢

Outline of Final Research Achievements

We investigated the relationship of night and shift work and four year change of serum prostatic specific antigen (PSA) and one year change of adrenal androgen (DHEA-S). The numbers of subjects were 251 employees aged 50 and over for PSA study and 756 employees aged 40 and over for DHEA-S study. The number of participants whose PSA exceeded the normal range after 4 years was eleven. Night work or shift work did not show any relationship for increase of PSA. DHEA-S decreased with age. The level and trend of changes of DHEA-S for one year was different among the groups categorised by work schedule. Participants engaged in night work showed more decrease of DHEA-S compared with others. It suggested that night work might accelerate an aging change of DHEA-S. However, the effects of night work on prostate should be studied more.

Free Research Field

医歯薬学