2015 Fiscal Year Final Research Report
Study for pathological Analysis and clinical intervention of pulmonary MAC disease
| Project/Area Number |
25461178
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | National Institute of Infectious Diseases |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
Hasegawa Naoki 慶應義塾大学, 医学部 感染制御部, 教授 (20198724)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 抗酸菌 / 細胞性免疫 / 液性免疫 / ワクチン |
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| Outline of Final Research Achievements |
Using Enzyme-Linked ImmunoSpot and Enzyme-Linked ImmunoSorbent Assays, we observed less correlation of both cellular medicated immunity and IgG titers with patient clinical status. However IgA titers were significantly correlated with clinical status, suggesting that specific IgA antibodies protect proliferation. In addition, in some cases, IgA antibody titers were significantly associated with the serum concentration of total albumin, which supports the idea that humoral immunity can be influenced by the nutritional status. Based on these observations, we propose that the induction of humoral immunity should be included as an option in vaccine development strategies.
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| Free Research Field |
呼吸器内科学
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