Elucidation of pathogenesis of the onset of lifestyle-related diseases due to oxidative stress derived from diet components

2015 Fiscal Year Final Research Report

• Project/Area Number: 25461372
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Metabolomics
• Research Institution: The Institute for Adult Diseases Asahi Life Foundation
• Principal Investigator: Kushiyama Akifumi 公益財団法人朝日生命成人病研究所, その他部局等, 教授 (30435820)
• Co-Investigator(Renkei-kenkyūsha): SAKODA Hideyuki 宮崎大学, 第三内科, 講師 (50376464) ; ASANO Tomoichirou 広島大学, 大学院医歯薬保健学研究院, 教授 (70242063) ; KURIHARA Hiroki 東京大学, 大学院医学研究科, 教授 (20221947)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 生活習慣病 / 尿酸 / キサンチンオキシダーゼ

Outline of Final Research Achievements

The diet components, especially sugar and lipid, are closely related to the development of lifestyle-related diseases. Although, the components are strongly influenced to the activity of Xanthine oxidoreductase, XOR, playing a role as rate-limiting enzyme of uric acid metabolism with accompanying ROS generation.
Our previous study clarified the involvement of macrophage-derived XOR activity in pathogenesis of atherosclerosis. In this study, I established the mice strains which change tissue-specific expression of XOR. They were fed with a various diets' load and their lifestyle-related diseases get worse. The analysis of these mice were partly clarified the involvement of the XOR activation due to the diet component.

Free Research Field

代謝学