2015 Fiscal Year Final Research Report
Control of inhibitory immunoreceptor in cell therapy after allogeneic hematopoietic stem cell transplantation
| Project/Area Number |
25461446
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Hematology
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| Research Institution | Nagoya University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
ITO Yoshinori 名古屋大学, 医学系研究科, 准教授 (20373491)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 免疫抑制受容体 / 抗原特異的T細胞 / 抗原提示細胞 / 細胞療法 |
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| Outline of Final Research Achievements |
Adenovirus serotype 11 (AdV-11) occasionally causes hemorrhagic cystitis after allogeneic hematopoietic stem cell transplantation. A novel T-cell epitope (TYFNLGNKF) of AdV-11 presented by HLA-A*24:02 was identified, and the epitope indeed functions as a target for TYFNLGNKF-specific T cells in vivo. It was demonstrated that antigen-specific T cells could be generated rapidly and efficiently by the use of anti-4-1BB antibody without antigen-presenting cells. And PD-L1 expressed on antigen-presenting cells along with CD80/86 showed to enhance the induction of antigen-specific T cells. These findings are applicable to cell therapy in the future.
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| Free Research Field |
血液内科学
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