The analysis of myeloid-derived suppressor cells related with the pathogenesis of rheumatoid arthritis and development of a new therapy

2015 Fiscal Year Final Research Report

• Project/Area Number: 25461480
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Collagenous pathology/Allergology
• Research Institution: Kyoto Prefectural University of Medicine
• Principal Investigator: KAWAHITO YUTAKA 京都府立医科大学, 医学(系)研究科(研究院), 准教授 (50336731)
• Co-Investigator(Kenkyū-buntansha): KOHNO MASATAKA 京都府立医科大学, 医学研究科, 講師 (60405256) ; ASHIHARA EISHI 京都薬科大学, 薬学部, 教授 (70275197) ; YAMAMOTO AIHIRO 京都府立医科大学, 医学研究科, 助教 (60589878)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 関節リウマチ / 骨髄由来抑制細胞

Outline of Final Research Achievements

In this study, MDSCs (Myeloid-derived suppressor cells) accumulated in the spleens of mice with CIA (collagen induce arthritis) when arthritis severity peaked. These MDSCs inhibited the proliferation of CD4+ T cells and their differentiation into Th17 cells in vitro. Moreover, MDSCs inhibited IFN-γ, IL-2, TNFα, and IL-6 by CD4+ T cells in vitro, which is antigen non-specific T cell response. Adoptive transfer of MDSCs reduced the severity of CIA in vivo. In conclusion, MDSCs in CIA suppress the progression of CIA by inhibiting the pro-inflammatory immune response of CD4+ T cells. These observations suggest that MDSCs play crucial roles in the regulation of autoimmune arthritis, which could be exploited in new cell-based therapies for human rheumatoid arthritis.

Free Research Field

膠原病・リウマチ学