2015 Fiscal Year Final Research Report
Analysis of a mouse model showing autism-related behavioral abnormalities
| Project/Area Number |
25461567
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Matsuyama University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
FURUKAWA YOSHIKO 松山大学, 薬学部, 教授 (20219108)
OKUYAMA SATOSHI 松山大学, 薬学部, 助教 (40550380)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 自閉症 |
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| Outline of Final Research Achievements |
Wnt1-cre and Wnt1-GAL4 double transgenic (dTg) mice are used to study neural crest cell lineages, and are achieved utilizing either the Cre/loxP or GAL4/UAS system. In the present study, we demonstrated behavioral abnormalities in dTg mice that are associated with psychiatric disorders, such as increased locomotor activity, decreased social behavior, and an increased frequency in vertical jumping. Of these, the proclivity for vertical jumping was observed only in male dTg mice. In contrast, MK-801 administration induced hyperlocomotion in only the female dTg mice, which was subsequently rescued by treatment with clozapine. Furthermore, the concentrations of prolactin in the sera, and oxytocin in the hypothalamus, were both reduced only in female dTg mice, compared to controls. These results suggest that the phenotype of psychiatric disorders may be influenced by gender-gene interactions.
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| Free Research Field |
医歯薬学
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