Biological response and therapeutic intervention in pediatric critical and intractable diseases

2015 Fiscal Year Final Research Report

• Project/Area Number: 25461594
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Pediatrics
• Research Institution: Okayama University
• Principal Investigator: Hirokazu Tsukahara 岡山大学, 医歯(薬)学総合研究科, 教授 (90207340)
• Research Collaborator: OKADA Ayumi 岡山大学, 医歯薬学総合研究科, 准教授 (70325108) ; BABA Kenji 岡山大学, 大学病院, 講師 (40721767) ; YASHIRO Masato 岡山大学, 大学病院, 助教 (80585943) ; MIYAI Takayuki 岡山大学, 大学病院, 助教 (50423330) ; YOSHIMOTO Junko 岡山大学, 大学病院, 助教 (20570526) ; WASHIO Yosuke 岡山大学, 大学病院, 助教 (20569066) ; FUJII Yosuke 岡山大学, 医歯薬学総合研究科, 助教 (80549775)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 小児医療 / 生体応答 / 酸化ストレス / 一酸化窒素

Outline of Final Research Achievements

It is becoming increasingly apparent that reactive oxygen species (ROS) exert multiple biological effects over a wide spectrum, from physiological regulatory functions to the pathogenesis of diverse diseases. We sought for the clinical application of oxidative stress biomarkers in pediatric medicine. First, we explained important physiological and pathophysiological aspects of ROS and antioxidative defense systems. Second, we presented a list of clinically applicable biomarkers, along with pediatric diseases in which enhanced oxidative stress might be involved. Many good biomarkers are readily measurable using ELISA. Rapid diagnostic tests for measuring oxidative stress status (such as hydroperoxides, 8-OHdG, L-FABP) have been introduced. Third, we have evaluated the efficacy of antioxidative intervention for oxidative-stress related diseases using several animal models. Last, although not comprehensive, we provided a brief perspective of this particular area in pediatric research.

Free Research Field

小児科