2015 Fiscal Year Final Research Report
Functional examination of CD147/Basigin as a regulator of tumor cell survival.
| Project/Area Number |
25461702
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Dermatology
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| Research Institution | Kagoshima University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Keywords | CD147/Basigin / 皮膚癌 / 治療 |
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| Outline of Final Research Achievements |
We examined the function of CD147/Basigin as a regulator of tumor cell survival using a malignant melanoma cell line that expresses high level of CD147/Basigin. CD147/Basigin had no functional relation with ER signaling and autophagy which are the main defense systems against cellular stress. We found that CD147 activates EGFR which plays an important role in the cell proliferation and showed that cell growth was inhibited by the EGFR inhibitor and CD147 silencing, and additive growth inhibition was observed when these ttreatments were combined. These results would yield a improvement of therapeutic outcome in clinical settings.
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| Free Research Field |
皮膚科学
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