The basic research of the change of mood by zinc deficiency and social isolation

2015 Fiscal Year Final Research Report

• Project/Area Number: 25461753
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: University of Fukui
• Principal Investigator: Omata Naoto 福井大学, 医学部附属病院, 講師 (30334832)
• Co-Investigator(Kenkyū-buntansha): KIYONO Yasushi 福井大学, 高エネルギー医学研究センター, 教授 (50305603)
• Research Collaborator: MIZUNO Tomoyuki 福井大学, 医学部病態制御医学講座精神医学領域, 協力研究員 ; MARUOKA Nobuyuki 福井大学, 医学部病態制御医学講座精神医学領域, 協力研究員
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 亜鉛欠乏 / 社会的隔離 / うつ様状態 / 躁様状態 / ノルエピネフリン / 神経可塑性

Outline of Final Research Achievements

Zinc deficiency (ZD) or/and Social Isolation (SI) were loaded to rats. ZD or SI alone increased anxiety-related behavior and depression-like behavior, but the co-occurrence of ZD and SI decreased them. ZD or SI alone decreased the expression of NE transporter in the locus coeruleus and the expression of brain-derived neurotrophic factor in the hippocampus, and the co-occurrence of ZD and SI made these incidences more prominent. These findings suggest that ZD or SI alone induces depressive state, but the co-occurrence of ZD and SI induces manic state, and that the impairment of NE system and neuronal plasticity contribute to these behavioral changes.

Free Research Field

気分障害