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2015 Fiscal Year Final Research Report

New regulation system for liver injury after surgery via immunological reaction against DAMPs

Research Project

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Project/Area Number 25461947
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field General surgery
Research InstitutionOkayama University

Principal Investigator

Shinoura Susumu  岡山大学, 大学病院, 助教 (40379772)

Co-Investigator(Kenkyū-buntansha) Takahashi Hideo  近畿大学, 医学部, 教授 (60335627)
Co-Investigator(Renkei-kenkyūsha) Sadamori Hiroshi  岡山大学, 医歯薬学総合研究科, 准教授 (30362974)
Project Period (FY) 2013-04-01 – 2016-03-31
KeywordsDAMPs / 肝障害 / HMGB1 / 外科侵襲
Outline of Final Research Achievements

Organ failure after surgery sometimes becomes a cause of death. We think hyper immunological response is one of this causes. I analyzed this immunoresponse system and studied for prognostic improvement of organ failure via immunological control.
I paid attention to HMGB1 in DAMPs which was a causative agent of the immunoresponse by the surgery. It was thought that HMGB1 participated in angiogenetic control via macrophage. The anti-HMGB1 mAb significantly ameliorated the degree of ischemia/reperfusion injury of the liver. We think this depends on hepatocellular proliferation.
HMGB1 control may enable improvement of ischemia/reperfusion injury of the liver.

Free Research Field

外科侵襲

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Published: 2017-05-10  

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