2016 Fiscal Year Final Research Report
Development of diagnostic method for acute rejection after kidney transplantation by blood / urinary metabolome analysis
| Project/Area Number |
25461963
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Tokyo Medical University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Keywords | 腎移植 / 急性拒絶反応 / メタボローム解析 |
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| Outline of Final Research Achievements |
We studied the development of diagnostic method for acute rejection after kidney transplantation by blood / urinary metabolome analysis. The group was divided into 3 groups such as donor group, normal renal function after renal transplantation, kidney function disorderafter renal transplantation group. As a result, there were 8 kinds of substances such as ADMA Dithanolamine, Glycerophosphorycholine, Isocitrate,Phe, SDMA, Serotonin, Valhaving significant difference compared with the control group, and 3 kinds such as 3-Indoxy sulfate, ADMA, N-Acetylhistidine were recognized with urine.
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| Free Research Field |
腎移植
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